adrenocortical function in bronchial asthma
نویسنده
چکیده
In a previous paper (Robson and Kilborn, 1965) we described some observations on adrenocortical function in continuous asthma. The methods employed were the cortisol production rate using an isotope dilution method (De Witt, Robson, and Stewart, 1962) and the specific measurement of plasma cortisol during adrenocorticotrophic hormone (A.C.T.H.) stimulation by a continuous intravenous infusion (Cameron and Kilborn, 1964). The patients were investigated when their asthma was quiescent, and no patient had previously received corticosteroid therapy. The results obtained showed that the cortisol production rate (21 patients) was within normal limits, but in 23 of 34 patients (68%) the adrenal cortex showed a diminished response to stimulation by A.C.T.H. The reason for the diminished reserve remained uncertain. It seemed conceivable that it could be due to a primary defect of the adrenal cortex or, on the other hand, secondary to a defect in A.C.T.H. production by the anterior pituitary. Further study seemed to be necessary, not only in regard to the above problem, but for the practical management of the disease. It appeared to be important to investigate the effect of treatment with corticosteroid drugs and corticotrophin on the adrenal function in these patients. With these points in mind, it was decided to reassess adrenal function in two groups of the original patients after treatment, one group having received prednisone and the other A.C.T.H.
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تاریخ انتشار 2004